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Reductions in Incidence of Invasive Group B Streptococcal Disease in the United States

Clyde Mitchell, MD
JAMA. 2008;300(14):1649-1650. doi:10.1001/jama.300.14.1649-a.
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To the Editor: The study of the epidemiology of invasive group B streptococcal disease in the United States by Dr Phares and colleagues1 found that intervention was associated with a reduction in incidence of 1.3 in every 10 000 live births. This absolute reduction seems small to me in spite of the 27% relative risk reduction. To accept these numbers as justification to continue current practice does not consider the cost of testing and therapy, the effects of antibiotic therapy on resistance patterns, or the differential treatment of otherwise well newborns. Starting all infants exposed to group B streptococcus with intravenous antibiotic therapy would certainly result in morbidity. It is not clear that group B streptococcal screening and treatment of all culture-positive mothers would result in a net benefit.

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October 8, 2008
Ralph K. H. Nanan, PhD, FRACP; Gurvinder Singh, MBBS; Alison Poulton, MBBChir, MRCP, FRACP
JAMA. 2008;300(14):1649-1650. doi:10.1001/jama.300.14.1649-b.
October 8, 2008
Christina Phares, PhD; Anne Schuchat, MD; Stephanie Schrag, DPhil
JAMA. 2008;300(14):1649-1650. doi:10.1001/jama.300.14.1650-a.
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