0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Lab Reports |

Clues to Preeclampsia

Tracy Hampton, PhD
JAMA. 2008;300(13):1508. doi:10.1001/jama.300.13.1508-a.
Text Size: A A A
Published online

Extract

New research, in which pregnant mice injected with antibodies from pregnant women with preeclampsia in turn exhibit key features of the condition, suggests that preeclampsia may be a pregnancy-induced autoimmune disease (Zhou CC et al. Nat Med. 2008;14[8]:855-862).

Currently, there is no effective treatment for preeclampsia, in part because of the lack of a complete understanding of the disease.

Some studies have shown that women with preeclampsia have autoantibodies that activate a receptor called angiotensin II type 1a (AT1 receptor), which is involved with blood pressure regulation. In the current work, led by investigators at the University of Texas Medical School at Houston, pregnant mice injected with these antibodies exhibited such hallmarks of preeclampsia as hypertension, proteinuria, glomerular endotheliosis, placental abnormalities, and small fetus size. These features were prevented when the mice also were injected with losartan, an AT1 receptor antagonist.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Letters

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();