Author Contributions: Drs Tzemos and Siu had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Tzemos, Therrien, Yip, Webb, Siu.
Acquisition of data: Tzemos, Yip, Thanassoulis, Tremblay, Jamorski, Siu.
Analysis and interpretation of data: Tzemos, Therrien, Yip, Webb, Siu.
Drafting of the manuscript: Tzemos, Siu.
Critical revision of the manuscript for important intellectual content: Tzemos, Therrien, Yip, Thanassoulis, Tremblay, Jamorski, Webb, Siu.
Statistical analysis: Siu.
Obtained funding: Siu.
Administrative, technical, or material support: Tzemos, Therrien, Yip, Thanassoulis, Tremblay, Jamorski, Webb, Siu.
Study supervision: Therrien, Webb, Siu.
Financial Disclosures: None reported.
Funding/Support: Dr Tzemos was partially supported by a fellowship grant from the University of Toronto Department of Medicine. Dr Thanassoulis was supported by a research fellowship from the Fonds de Recherche en Santé du Québec. The study was supported by operating grants from the Canadian Institutes of Health Research (grant 53130) and the Heart and Stroke Foundation of Canada (grant NA5662).
Role of the Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.