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Letters |

Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death—Reply

Dean Fergusson, MHA, PhD; Lauralyn McIntyre, MD, MSc
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1299.
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In Reply: We agree with Drs Sarani and Gracias that the concerning results from the HBOC trials should not deter future research on technologies to minimize or avoid allogeneic transfusion. We also agree with Dr Sauaia and colleagues that there may be additional circumstances such as emerging pathogens and national emergencies that threaten the adequacy or quality of the US blood supply. However, it is important to assess the clinical consequences of each threat or harm with robust and ethical methodology.

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September 17, 2008
Lewis J. Levien, MBBCh, PhD; Richard E. Hodgson, MBChB; Michael F. M. James, MBChB, PhD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1295-a.
September 17, 2008
Peter E. Keipert, PhD; Christina Olofsson, MD, PhD; Robert M. Winslow, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1295-b.
September 17, 2008
Roger J. Lewis, MD, PhD; Norman Fost, MD, MPH
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1296-a.
September 17, 2008
Aryeh Shander, MD; Mazyar Javidroozi, MD; Gary Thompson, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1296-b.
September 17, 2008
Angela Sauaia, MD, PhD; Ernest E. Moore, MD; Anirban Banerjee, PhD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1297-a.
September 17, 2008
Babak Sarani, MD; Vicente Gracias, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1297-b.
September 17, 2008
Charles Natanson, MD; Peter Lurie, MD, MPH; Sidney M. Wolfe, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1298.
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