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Letters |

Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death

Aryeh Shander, MD; Mazyar Javidroozi, MD; Gary Thompson, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1296-b.
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To the Editor: In their meta-analysis, Dr Natanson and colleagues1 described the hurdles they faced in accessing data from HBOC trials conducted by pharmaceutical companies. Although we agree that more transparency is needed to balance corporate and public interests, we consider it unacceptable to draw definite conclusions based on seemingly incomplete data.

Their review included trials of varying methodologies performed on heterogeneous patients in different settings with various controls. There may not have been statistical heterogeneity, but there was important clinical heterogeneity. For example, a core issue in HBOC trials is the comparator, and it seemed that blood and nonblood controls yielded similar results. However, although 2 large trials2,3 had mixed blood and nonblood controls, their results were incorrectly pooled with those of the remaining 14 trials in the corresponding subgroup analysis. Some supposedly “nonblood” controls may have received blood and vice versa.

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Letters

September 17, 2008
Lewis J. Levien, MBBCh, PhD; Richard E. Hodgson, MBChB; Michael F. M. James, MBChB, PhD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1295-a.
September 17, 2008
Peter E. Keipert, PhD; Christina Olofsson, MD, PhD; Robert M. Winslow, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1295-b.
September 17, 2008
Roger J. Lewis, MD, PhD; Norman Fost, MD, MPH
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1296-a.
September 17, 2008
Angela Sauaia, MD, PhD; Ernest E. Moore, MD; Anirban Banerjee, PhD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1297-a.
September 17, 2008
Babak Sarani, MD; Vicente Gracias, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1297-b.
September 17, 2008
Charles Natanson, MD; Peter Lurie, MD, MPH; Sidney M. Wolfe, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1298.
September 17, 2008
Dean Fergusson, MHA, PhD; Lauralyn McIntyre, MD, MSc
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1299.
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