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September 17, 2008, Vol 300, No. 11 >

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Letters | September 17, 2008

Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death

Roger J. Lewis, MD, PhD; Norman Fost, MD, MPH
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1296-a.
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To the Editor: From 1997 to early 1998, we were members of the data and safety monitoring board (DSMB) for Baxter Healthcare's US study of diaspirin cross-linked hemoglobin (DCLHb) in adult trauma patients experiencing hemorrhagic shock.1- 2 Thus, we read with interest the study by Dr Natanson and colleagues3 describing the cumulative experience and adverse outcomes associated with the use of hemoglobin-based blood substitutes (HBBSs).3 While the cumulative adverse outcome data for HBBSs speak for themselves, the authors imply there has been a consistent pattern of delay in the release and publication of negative trial results with HBBSs.

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September 17, 2008
Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death
Lewis J. Levien, MBBCh, PhD; Richard E. Hodgson, MBChB; Michael F. M. James, MBChB, PhD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1295-a.
September 17, 2008
Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death
Peter E. Keipert, PhD; Christina Olofsson, MD, PhD; Robert M. Winslow, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1295-b.
September 17, 2008
Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death
Aryeh Shander, MD; Mazyar Javidroozi, MD; Gary Thompson, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1296-b.
September 17, 2008
Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death
Angela Sauaia, MD, PhD; Ernest E. Moore, MD; Anirban Banerjee, PhD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1297-a.
September 17, 2008
Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death
Babak Sarani, MD; Vicente Gracias, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1297-b.
September 17, 2008
Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death—Reply
Charles Natanson, MD; Peter Lurie, MD, MPH; Sidney M. Wolfe, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1298.
September 17, 2008
Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death—Reply
Dean Fergusson, MHA, PhD; Lauralyn McIntyre, MD, MSc
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1299.
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