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Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death

Peter E. Keipert, PhD; Christina Olofsson, MD, PhD; Robert M. Winslow, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1295-b.
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To the Editor: Dr Natanson and colleagues1 published a meta-analysis attempting to compare the safety profile for 5 different HBOCs. They pooled adverse event data for MI and death from 16 diverse trials conducted from 1997 to 2007, with study populations ranging from 10 to more than 700 patients in a variety of cardiac, orthopedic, vascular, ischemic stroke, and trauma patient populations. The majority of data came from earlier generation products, including HemAssist (Baxter Healthcare, Deerfield, Illinois) and Hemolink (Hemosol Inc, Mississauga, Ontario, Canada), which were discontinued in 1998 and in 2004, respectively; Hemopure (Biopure); and PolyHeme (Northfield Laboratories, Evanston, Illinois). The pooled analysis concluded that HBOCs were associated with a significantly increased risk of death and MI.

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September 17, 2008
Lewis J. Levien, MBBCh, PhD; Richard E. Hodgson, MBChB; Michael F. M. James, MBChB, PhD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1295-a.
September 17, 2008
Roger J. Lewis, MD, PhD; Norman Fost, MD, MPH
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1296-a.
September 17, 2008
Aryeh Shander, MD; Mazyar Javidroozi, MD; Gary Thompson, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1296-b.
September 17, 2008
Angela Sauaia, MD, PhD; Ernest E. Moore, MD; Anirban Banerjee, PhD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1297-a.
September 17, 2008
Babak Sarani, MD; Vicente Gracias, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1297-b.
September 17, 2008
Charles Natanson, MD; Peter Lurie, MD, MPH; Sidney M. Wolfe, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1298.
September 17, 2008
Dean Fergusson, MHA, PhD; Lauralyn McIntyre, MD, MSc
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1299.
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