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Letters |

Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death

Lewis J. Levien, MBBCh, PhD; Richard E. Hodgson, MBChB; Michael F. M. James, MBChB, PhD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1295-a.
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To the Editor: The meta-analysis of cell-free hemoglobin-based blood substitutes and risk of myocardial infarction (MI) and death by Dr Natanson and colleagues1 and the accompanying Editorial by Drs Fergusson and McIntyre2 raise serious concerns for clinicians treating life-threatening anemia in South Africa, the only country where a hemoglobin solution (Hemopure, Biopure Corp, Cambridge, Massachusetts) is registered for clinical use.

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Letters

September 17, 2008
Peter E. Keipert, PhD; Christina Olofsson, MD, PhD; Robert M. Winslow, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1295-b.
September 17, 2008
Roger J. Lewis, MD, PhD; Norman Fost, MD, MPH
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1296-a.
September 17, 2008
Aryeh Shander, MD; Mazyar Javidroozi, MD; Gary Thompson, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1296-b.
September 17, 2008
Angela Sauaia, MD, PhD; Ernest E. Moore, MD; Anirban Banerjee, PhD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1297-a.
September 17, 2008
Babak Sarani, MD; Vicente Gracias, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1297-b.
September 17, 2008
Charles Natanson, MD; Peter Lurie, MD, MPH; Sidney M. Wolfe, MD
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1298.
September 17, 2008
Dean Fergusson, MHA, PhD; Lauralyn McIntyre, MD, MSc
JAMA. 2008;300(11):1295-1299. doi:10.1001/jama.300.11.1299.
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