Author Contributions: Dr Limaye had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Limaye, Bulger, Neff, Gibran, Corey, Boeckh.
Acquisition of data: Limaye, Huang, Santo Hayes, Boeckh.
Analysis and interpretation of data: Limaye, Kirby, Rubenfeld, Leisenring, Gibran, Boeckh.
Drafting of the manuscript: Limaye, Kirby, Leisenring.
Critical revision of the manuscript for important intellectual content: Limaye, Kirby, Rubenfeld, Leisenring, Bulger, Neff, Gibran, Huang, Santo Hayes, Corey, Boeckh.
Statistical analysis: Limaye, Kirby, Rubenfeld, Leisenring, Neff.
Obtained funding: Limaye, Boeckh.
Administrative, technical, or material support: Limaye, Bulger, Gibran, Huang, Santo Hayes, Corey, Boeckh.
Study supervision: Limaye, Leisenring, Boeckh.
Financial Disclosures: Dr Limaye reports having received research funding and speaking and/or consulting fees from Roche Laboratories and Genentech Inc and research funding from Viropharma Inc. Dr Corey reports having received grant support from GlaxoSmithKline and Novartis, 2 companies that make antiviral drugs for the treatment of herpes viruses; however, he receives no salary support from these studies. Dr Boeckh reports having received research funding and speaking and consulting fees from Roche Laboratories and Viropharma Inc, research funding and consulting fees from Novartis, research funding from Vical Inc, and consulting fees from AiCuris AG, Chimerix Inc, and Alpha Vax Inc. No other disclosures were reported.
Funding/Support: This investigator-initiated study was supported in part by Roche Laboratories Inc. and by National Institutes of Health grant CA-18029.
Role of the Sponsor: The funding sources for the study had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.
Previous Presentation: This study was presented in part at the American Thoracic Society International Conference, May 20, 2007, San Francisco, California (abstract 406).
Additional Contributions: We are grateful to Lucretia Granger, BSc, University of Washington, for coordinating the study and to Elaine Brooks, University of Washington, for assistance with manuscript preparation. No compensation was received.