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Commentary |

Heart Failure With Preserved Ejection Fraction:  Treat Now by Treating Comorbidities

Sanjiv J. Shah, MD; Mihai Gheorghiade, MD
JAMA. 2008;300(4):431-433. doi:10.1001/jama.300.4.431.
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Heart failure (HF) is a major public health problem, with a prevalence of more than 5 million cases and an incidence of 660 000 new cases per year in the United States alone.1Quiz Ref IDAmong patients older than 65 years, HF has become the most common discharge diagnosis and the primary cause of readmission within 60 days of discharge, resulting in estimated costs of $34.8 billion per year.1 Nearly half of all patients with HF have a preserved ejection fraction (HFPEF).25 Patients with HFPEF have a high all-cause mortality after hospitalization for HF: 2.9%, in-hospital mortality4; 9.5%, 60- to 90-day mortality4; 22% to 29%, 1-year mortality2,3; and 65%, 5-year mortality.2,3 These data underscore the urgent need to find ways to improve outcomes for these patients.

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