BRFSS is a state-based, random-digit–dialed telephone survey of the U.S. civilian, noninstitutionalized population aged ≥18 years and is conducted in all 50 states, DC, Guam, Puerto Rico, and the U.S. Virgin Islands. However, in 2005, the optional heart attack and stroke module was included in the BRFSS surveys of 13 states* and DC. A total of 71,994 respondents answered questions regarding symptoms of stroke.† An incorrect symptom was included in another question (“Do you think sudden chest pain or discomfort is a symptom of stroke?”) to assess the possibility that respondents might answer “yes” to all of the questions in the series without actually considering them. Respondents also were asked to select the one action they would do first, from the following list of actions, if they thought that someone was having a heart attack or stroke: take the person to the hospital, advise the person to call a doctor, call 9-1-1, call a spouse or family member, or do something else. Median response rate for the 13 states and DC, based on Council of American Survey and Research Organizations (CASRO) guidelines, was 54.5% (range: 45.1%-61.3%). Data were weighted to 2005 state population estimates. Age-adjusted prevalence estimates and 95% confidence intervals (CIs) were calculated; statistically significant differences between characteristics were determined by nonoverlapping CIs.