Several initiatives were launched by NYSDOH and ECDOH throughout Erie County to address the apparent clustering of HCV infection among injection-drug users. Staff members from NYSDOH, the NYS Office of Alcoholism and Substance Abuse Services, and ECDOH conducted cross-training sessions and developed a resource manual to help identify primary care, sexually transmitted disease (STD)/human immunodeficiency virus (HIV) screening, drug treatment, harm reduction, and HCV treatment services for patients. All interviewed patients were referred to ECDOH counselors for HIV/acquired immunodeficiency syndrome (AIDS) risk assessment and personalized intervention development. ECDOH conducted multiple events held at various community locations and ECDOH clinics, offering HCV, HIV, and STD screening, referral for services, and education on prevention, risk reduction, and family planning; these services are ongoing at all five ECDOH clinics. Presentations on hepatitis epidemiology, diagnosis and testing, and prevention were conducted at medical practices that serve high-risk communities throughout Erie County. ECDOH also collaborated with the Erie County Department of Mental Health to integrate HCV messages into existing prevention programs and implement screening programs in target areas with high HCV infection rates. Finally, ECDOH worked with school district representatives and high schools to address prevention of IDU and HCV transmission.