Letters entertain you, letters make you smile. But they also perform a very important and serious function, providing a forum for the scientific interaction between JAMA’s authors and its readers. The peer review system, which is the foundation for evaluating medical studies, includes multiway dialogues among authors, editors, and expert peer reviewers in an iterative process that results in evolution and refinement of a manuscript, ultimately leading to publication. However, the process does not end at this point—postpublication peer review is an integral part of the system and for JAMA this is manifest in Letters to the Editor.
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