Author Contributions: Drs Bjornsson, Sigurdsson, and Fallin contributed equally to this work. Drs Bjornsson, Feinberg, Fallin, Irizarry, Aspelund, Gudnason, and Feinberg had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Bjornsson, Fallin, Leppert, Sapienza, Gudnason, Feinberg.
Acquisition of data: Bjornsson, Sigurdsson, Cui, Yu, Rongione, Ekström, Harris, Launer, Eiriksdottir, Leppert, Sapienza, Gudnason.
Analysis and interpretation of data: Bjornsson, Sigurdsson, Fallin, Irizarry, Aspelund, Rongione, Sapienza, Gudnason, Feinberg.
Drafting of the manuscript: Bjornsson, Fallin, Aspelund, Feinberg.
Critical revision of the manuscript for important intellectual content: Bjornsson, Sigurdsson, Fallin, Irizarry, Aspelund, Cui, Yu, Rongione, Ekström, Harris, Launer, Eiriksdottir, Leppert, Sapienza, Gudnason, Feinberg.
Statistical analysis: Bjornsson, Fallin, Irizarry, Aspelund, Sapienza.
Obtained funding: Fallin, Launer, Sapienza, Gudnason, Feinberg.
Administrative, technical, or material support: Sigurdsson, Fallin, Cui, Yu, Rongione, Ekström, Harris, Eiriksdottir, Leppert, Sapienza, Gudnason, Feinberg.
Study supervision: Bjornsson, Fallin, Feinberg.
Financial Disclosures: None reported.
Funding/Support: This work was supported by National Institutes of Health (NIH) grants P50-HG003233 (Dr Feinberg) and R01-ES015211 (Dr Fallin), the Swedish Cancer Foundation (Dr Ekström), NIH contract N01-AG-12100 (Drs Harris, Launer, and Gudnason), the Icelandic Parliament (Dr Gudnason), Huntsman General Clinical Research Center grant M01-RR00064 (Dr Leppert), and the W. M. Keck Foundation and George S. and Delores Doré Eccles Foundation (Dr Leppert). Dr Bjornsson was supported by the Fulbright Foundation and Dr Sigurdsson was supported by a 2006 grant from the Icelandic Student Innovation Fund.
Role of the Sponsor: Drs Harris and Launer from the NIH helped design the AGES cohort, but otherwise, the study's funders had no role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.
Additional Contributions: We thank Andreas Peiffer, MD, and Melissa M. Dixon, MS, University of Utah, for technical assistance. No compensation was received.