Author Contributions: Dr Weber had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Weber, Vander Stoep, Weiss, Biederman, McClellan.
Acquisition of data: Weber, McCarty.
Analysis and interpretation of data: Weber, Vander Stoep, Weiss, Biederman, McClellan.
Drafting of the manuscript: Weber.
Critical revision of the manuscript for important intellectual content: Weber, McCarty, Vander Stoep, Weiss, Biederman, McClellan.
Statistical analysis: Weber, Vander Stoep.
Obtaining funding: Weber, Biederman, McClellan.
Administrative, technical, or material support: Weber, McCarty, Biederman, McClellan.
Study supervision: Weber, Biederman, McClellan.
Financial Disclosures: Dr Biederman reports that he currently receives research support from the following sources: Alza, AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Janssen Pharmaceuticals, McNeil, Merck, Organon, Otsuka, Shire, the National Institute of Mental Health, and the National Institute of Child Health and Human Development; that he is currently a consultant/advisory board member for the following pharmaceutical companies: Janssen, McNeil, Novartis, and Shire; that he is currently a speaker for the following speaker's bureaus: Janssen, McNeil, Novartis, Shire, and UCB Pharma; and that in previous years, he received research support, consultation fees, or speaker's fees for/from the following additional sources: Abbott, AstraZeneca, Celltech, Cephalon, Eli Lilly, Esai, Forest, Glaxo, Gliatech, the National Alliance for Research on Schizophrenia and Depression, the National Institute on Drug Abuse, New River, Novartis, Noven, Neurosearch, Pfizer, Pharmacia, the Prechter Foundation, the Stanley Foundation, and Wyeth. No other disclosures were reported.
Funding/Support: This project was supported by grants K23AT000929 and T32AT00815 from the National Center for Complementary and Alternative Medicine. Study medication and placebo were provided by Vital Nutrients Inc. The formulation of H perforatum used in the study is marketed as Hypericum 0.3%.
Role of the Sponsors: Neither sponsor had a role in the design and conduct of the study, in the collection, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.
Disclaimer: The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of the National Center for Complementary and Alternative Medicine, National Institutes of Health.
Additional Contributions: We are grateful to the Bastyr University staff who were compensated to enter data and manage the database of the study: Sandra L. Schildt, BA, database manager; Eden K. Pudberry, MS, naturopathic medical student; Cecily C. Schuler, BS, naturopathic medical student; and Deborah S. Box, BA, naturopathic medical student. Bastyr University Professor Leanna J. Standish, ND, PhD, LAc, provided assistance with the conception of the study design as an uncompensated mentor. We are also grateful to the families who participated in the study.