Author Contributions: Drs Frikke-Schmidt and Tybjærg-Hansen had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Frikke-Schmidt, Nordestgaard, Schnohr, Tybjærg-Hansen.
Acquisition of data: Frikke-Schmidt, Nordestgaard, Sethi, Remaley, Schnohr, Grande, Tybjærg-Hansen.
Analysis and interpretation of data: Frikke-Schmidt, Nordestgaard, Stene, Sethi, Remaley, Tybjærg-Hansen.
Drafting of the manuscript: Frikke-Schmidt, Tybjærg-Hansen.
Critical revision of the manuscript for important intellectual content: Frikke-Schmidt, Nordestgaard, Stene, Sethi, Remaley, Schnohr, Grande, Tybjærg-Hansen.
Statistical analysis: Frikke-Schmidt, Stene, Tybjærg-Hansen.
Obtained funding: Frikke-Schmidt, Nordestgaard, Schnohr, Tybjærg-Hansen.
Administrative, technical, or material support: Frikke-Schmidt, Nordestgaard, Sethi, Remaley, Grande, Tybjærg-Hansen.
Study supervision: Frikke-Schmidt, Grande, Tybjærg-Hansen.
Financial Disclosures: Dr Tybjærg-Hansen reported having received lecture fees from Pfizer and sanofi-aventis. Dr Nordestgaard reported being a consultant for Merck, Pfizer, BG Medicine, and AstraZeneca. No other authors reported any financial disclosures.
Funding/Support: This work was supported by a Specific Targeted Research Project grant from the European Union, Sixth Framework Programme Priority (FP-2005-LIFESCIHEALTH-6) contract 037631, the Danish Medical Research Council, the Danish Heart Foundation, the Research Fund at Rigshospitalet, Copenhagen University Hospital, Chief Physician Johan Boserup and Lise Boserup's Fund, Ingeborg and Leo Dannin's Grant, and Henry Hansen's and Wife's grant.
Role of the Sponsor: The study sponsors had no role in the conduct of the study, in the collection, management, analysis, or interpretation of data, or in the preparation, review, or approval of the manuscript.
Additional Contributions: We thank senior technician Mette Refstrup (Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark), for her persistent attention to the details of the large-scale genotyping. Ms Refstrup did not receive any compensation for her contribution. We are indebted to the staff and participants of the Copenhagen City Heart Study and the Copenhagen General Population Study for their important contributions.