Author Contributions: Dr Robinson had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Robinson, Jorge, Solodkin, Fonzetti, Hegel.
Acquisition of data: Robinson, Jorge, Solodkin, Small, Fonzetti.
Analysis and interpretation of data: Robinson, Jorge, Moser, Acion, Small, Arndt.
Drafting of the manuscript: Robinson, Jorge, Acion, Fonzetti, Hegel.
Critical revision of the manuscript for important intellectual content: Moser, Acion, Solodkin, Small, Hegel, Arndt.
Statistical analysis: Jorge, Acion, Arndt.
Obtained funding: Robinson, Solodkin.
Administrative, technical, or material support: Robinson, Solodkin, Small, Fonzetti.
Study supervision: Moser, Hegel.
Financial Disclosures: All of the authors received salary contributions from the grant supporting this study. Over the past 5 years, Dr Robinson reports serving as a consultant to the former Hamilton Pharmaceutical Company and Avanir Pharmaceutical Company; Dr Jorge reports receiving 2 travel awards to participate in national meetings from the former Hamilton Pharmaceutical Company and Avanir Pharmaceutical Company; and Dr Small reports that he conducted a research study funded by Northstar Neuroscience that was unrelated to this prevention study. The former Hamilton Pharmaceutical Company and Avanir Pharmaceutical Company had no financial interest in this prevention study. No other authors reported any financial disclosures.
Data and Safety Monitoring Board: Russell Noyes, MD, Harold Adams, MD, and Douglas Langbehn, MD, University of Iowa.
Funding/Support: This work was supported solely by National Institute of Mental Health (NIMH) grant R01 MH-65134. All of the study medications were purchased using NIMH grant funds.
Role of the Sponsor: NIMH did not participate in the design and conduct of the study; collection, management, analysis, and interpretation of the data; or preparation, review, or approval of the manuscript.
Additional Contributions: We thank Stephanie Rosazza, BA, University of Iowa, for study coordination; Teresa Kopel, MA, University of Iowa, for administering problem-solving therapy; Jessica Thompson, BS, University of Chicago, for administering problem-solving therapy; and Mireya Montalvan, BA, Burke Rehabilitation Hospital, for performing neuropsychological assessment. None of these individuals received compensation for their work in association with this article.