0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Letters |

Glucose-Insulin-Potassium Therapy in Patients With STEMI

Harry P. Selker, MD, MSPH; Joanne Ingwall, PhD; Charles E. Rackley, MD
JAMA. 2008;299(20):2385-2388. doi:10.1001/jama.299.20.jlt0528-a.
Text Size: A A A
Published online

Extract

To the Editor: We have concerns about possible conclusions of the study of glucose-insulin-potassium (GIK) therapy in patients with ST-segment elevation myocardial infarction (STEMI) by Dr Díaz and colleagues,1 which combined patients from the early-terminated OASIS-6 (Organization for the Assessment of Strategies for Ischemic Syndromes 6) trial with their previously published CREATE-ECLA Trial (Clinical Trial of Reviparin and Metabolic Modulation in Acute Myocardial Infarction Treatment and Evaluation–Estudios Clinicos Latino America).2 In the earlier article, the investigators commented on a possible relationship between hyperglycemia and mortality. In a post hoc analysis in the study by Díaz et al,1 there was again an association of higher glucose with greater event rates, consistent with the association of diabetes mellitus with elevated glucose and with worse acute myocardial infarction (MI) outcomes.3 We do not believe that an inference of a causal link between mortality and GIK is justified by these data.

Topics

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

May 28, 2008
Ajay Chaudhuri, MD; Richard Nesto, MD; Paresh Dandona, MD, PhD
JAMA. 2008;299(20):2385-2388. doi:10.1001/jama.299.20.jlt0528-d.
May 28, 2008
Rohit R. Arora, MD; Srikanth Katragadda, MD
JAMA. 2008;299(20):2385-2388. doi:10.1001/jama.299.20.jlt0528-c.
May 28, 2008
Lionel H. Opie, MD, DPhil
JAMA. 2008;299(20):2385-2388. doi:10.1001/jama.299.20.jlt0528-b.
May 28, 2008
Abhinav Goyal, MD, MHS; Rafael Díaz, MD; Shamir R. Mehta, MD, MSc
JAMA. 2008;299(20):2385-2388. doi:10.1001/jama.299.20.jlt0528-e.
CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Jobs
brightcove.createExperiences();