Author Contributions: Dr Jacobs had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Holvoet, Lee, Steffes, Gross, Jacobs.
Acquisition of data: Holvoet, Gross, Jacobs.
Analysis and interpretation of data: Holvoet, Lee, Steffes, Gross, Jacobs.
Drafting of the manuscript: Holvoet, Lee.
Critical revision of the manuscript for important intellectual content: Holvoet, Lee, Steffes, Gross, Jacobs.
Statistical analysis: Lee, Jacobs.
Obtained funding: Gross, Jacobs.
Administrative, technical, or material support: Holvoet, Steffes, Gross, Jacobs.
Study supervision: Holvoet, Jacobs.
Financial Disclosures: Dr Holvoet reports being the inventor of the assay for oxidized LDL for which patents have been granted in Europe (EP 1110092) and the United States (US Patent 6.309.888 and US Patent 6.727.102). All rights on inventions made by members of the university are vested by KU Leuven Research & Development, the technology transfer unit of the Katholieke Universiteit Leuven, which also receives any royalties. KU Leuven Research & Development granted a license to National Screening Institute (NSI; Newport Beach, California) who gave a sublicense to Mercodia (Uppsala, Sweden). Neither NSI nor Mercodia was involved in this research in any way. None of the other authors reported disclosures.
Funding/Support: This study was supported in part by National Heart, Lung, and Blood Institute contracts N01-HC-48047, N01-HC-48048, N01-HC-48049, N01-HC-48050, N01-HC-95095 (CARDIA Study), and 1RO1-HL53560 (YALTA Study). Additional funding was provided by the School of Public Health, University of Minnesota fund supporting Dr Jacobs' Mayo professorship, by the Interuniversitaire Attractiepolen Programma of the Belgian Federal Government (P06/30), and by the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (G.0232.05).
Role of the Sponsor: The National Heart, Lung, and Blood Institute participates in the governance of CARDIA and reviewed the manuscript.Otherwise, none of the funding organizations had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
Additional Contributions: We thank M. Landeloos (laboratory technician employed by the Katholieke Universiteit Leuven) for excellent technical assistance, for which she did not receive additional compensation beyond her regular salary.