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CCB/ACE Inhibitor Dual Therapy for Hypertension Lowers Cardiovascular Risk

Mike Mitka
JAMA. 2008;299(19):2263-2264. doi:10.1001/jama.299.19.2263.
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Chicago—Findings from a new study challenge current guidelines for the treatment of stage 2 hypertension.

The study's findings, presented at the American College of Cardiology's annual scientific session here in March, found that high-risk patients with hypertension who received a calcium-channel blocker (CCB) combined with an angiotensin-converting enzyme (ACE) inhibitor experienced 20% less cardiovascular morbidity and mortality than did patients taking an ACE inhibitor plus a thiazidetype diuretic. The difference was so significant that the study was stopped early.

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A low-cost combination therapy that includes a calcium-channel blocker and an angiotensin-converting enzyme inhibitor may provide the best control of stage 2 hypertension while reducing risk for cardiovascular events.

(Photo credit: Robert Bremec/iStockphoto.com)



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