Scientists and investigators are probing the possibility that botulinum toxins may migrate from the site of injection and may cause unintended effects including weakening adjacent muscles.
As the myriad clinical uses for botulinum toxins continue to expand, scientists examining their mechanism of action in animal models have demonstrated that these neurotoxins may have a measurable effect on muscles adjacent to the injection site. They also have identified pathways by which the toxins may travel in the nervous system and cause distant neurological effects. The findings have emerged as the US Food and Drug Administration (FDA) investigates reports of adverse reactions in patients treated with botulinum toxin that suggest spread of toxin beyond the injection site.
Graphic Jump Location
Scientists have documented that the poisonous light chain (purple) of botulinum toxin type A can move from one synapse to the next.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 12
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.