In recent years there have been unprecedented advances in the understanding of the epidemiology, pathophysiology, and treatment of sepsis syndrome.1- 3 This work has culminated in several clinical trials demonstrating the efficacy of targeted interventions to improve sepsis-related outcomes.4- 6 These interventions include not only novel therapeutic agents such as drotrecogin alfa but also treatments directed at improving the way more traditional therapy is delivered, such as early resuscitation and low-tidal volume ventilation for acute lung injury.4- 6
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