Study concept and design: Schultz, Dehlendorff, Jensen, Andersen, Johansen.
Acquisition of data: Schultz, Jensen, Bjerregaard, K. Nielsen, Bojesen, Calatayud, S. Nielsen, Yilmaz, Holländer, Johansen.
Analysis and interpretation of data: Schultz, Dehlendorff, Bjerregaard, Andersen, Johansen.
Drafting of the manuscript: Schultz, Dehlendorff, Andersen, Johansen.
Critical revision of the manuscript for important intellectual content: Schultz, Dehlendorff, Jensen, Bjerregaard, K. Nielsen, Bojesen, Calatayud, S. Nielsen, Yilmaz, Holländer, Andersen, Johansen.
Statistical analysis: Schultz, Dehlendorff, Andersen, Johansen.
Obtained funding: Jensen, Johansen.
Administrative, technical, and material support: Schultz, Jensen, K. Nielsen, Bojesen, Calatayud, S. Nielsen, Yilmaz, Holländer, Johansen.
Study supervision: Jensen, Bjerregaard, Holländer, Johansen.
Conflict of Interest Disclosures: The authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Drs Schultz, Jensen, Andersen, and Johansen reported that they are named in a European patent application, which has been submitted by the Copenhagen Region, Copenhagen University Hospital.
Funding/Support: The study was supported by grants from the Research Council at Herlev Hospital, the Joint Proof-of-Concept Fund (Ministry of Science, Technology and Innovation, Denmark), Region Hovedstadens forsknings fond til Sundhedsforskning, the Danish Cancer Society, Aase og Ejnar Danielsens Fond, and Prosektor Axel Søeborg Ohlsen og Else Søeborg Ohlsen Mindelegat.
Role of the Sponsor: The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contribution: We thank the biomedical laboratory scientists at the participating departments for excellent technical assistance with handling of blood samples. We also thank Astrid Z. Johansen and Lærke M. Nelson, MD, for registration of clinical data in the BIOPAC database. In addition, we thank the nurses and physicians at the participating departments for inclusion of patients in the BIOPAC study. We also thank the patients for their participation in this study.