Published Online: March 30, 2008 (doi:10.1001 /jama.299.15.joc80026).
Author Contributions: Dr Valgimigli had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Valgimigli, Campo, Bolognese, Parrinello, Ferrari.
Acquisition of data: Valgimigli, Campo, Percoco, Bolognese, Vassanelli, Colangelo, de Cesare, Rodriguez, Ferrario, Moreno, Piva, Pasquetto, Prati, Nazzaro.
Analysis and interpretation of data: Valgimigli, Campo, Percoco, Bolognese, Rodriguez, Sheiban, Parrinello.
Drafting of the manuscript: Valgimigli, Vassanelli, Colangelo, Moreno, Piva.
Critical revision of the manuscript for important intellectual content: Valgimigli, Bolognese, de Cesare, Rodriguez, Moreno, Sheiban, Pasquetto, Nazzaro, Ferrari.
Statistical analysis: Valgimigli, Percoco, Parrinello.
Obtained funding: Valgimigli.
Administrative, technical, or material support: Valgimigli, Campo, Percoco, Rodriguez, Nazzaro.
Study supervision: Bolognese, de Cesare, Ferrario, Moreno, Piva, Sheiban, Pasquetto, Ferrari.
Financial Disclosures: Dr Valgimigli reported receiving honoraria and research support from Merck, USA. Dr Prati reported receiving research grants from Eli Lilly Italia SPA and Merck Sharp & Dohme Italia SPA. No other authors reported financial disclosures.
Funding/Support: The study was an investigator-driven clinical trial conducted by the University of Ferrara. It was partially supported by a medical school grant from Merck, released in December 2005, while the study was recruiting patients.
Role of the Sponsor: Merck had no role in the design and conduct of the study; in the collection, analysis, and interpretation of the data; or in the preparation, review, or approval of the manuscript.
MULTISTRATEGY (Multicentre Evaluation of Single High-Dose Bolus Tirofiban vs Abciximab With Sirolimus-Eluting Stent or Bare Metal Stent in Acute Myocardial Infarction Study) Investigators:Executive committee: Marco Valgimigli, MD, PhD (principal investigator), University of Ferrara, Ferrara, Italy; Gianfranco Percoco, MD, University of Ferrara; Roberto Ferrari, MD, PhD, University of Ferrara; Data and Safety Monitoring board: Pascal Vranckx, MD, Virga Jesseziekenhuis, Hasselt, Belgium (chair); Clinical Events committee: Pierfrancesco Agostoni, MD, Antwerp Cardiovascular Institute Middleheim, AZ Middelheim, Antwerp, Belgium (chair); Emanuele Meliga, MD, Erasmus MC, Thoraxcenter, Rotterdam, the Netherlands; Salvatore Curello, MD, Spedali Civili, Brescia, Italy; Data Management and Monitoring: Stefania Gambetti, BSc, Medical Trial Analysis, Lugano, Switzerland; Anna Jurczynska, MSc, SERMES-CRO, Madrid, Spain (director); Statistical committee: Giovanni Parrinello, PhD, Medical Statistics Unit, University of Brescia, Brescian, Italy (chair); Core Angiographic Laboratorys: Patriza Malagutti, MD, Medical Trial Analysis, Ferrara, Italy (director); Core Electrocardiographic Laboratory: Chiara Arcozzi, MD, Medical Trial Analysis, Ferrara (director).
MULTISTRATEGY Clinical Sites: Cardiovascular Research Center (CECI)/Sanatorio Otamendi, Buenos Aires, Argentina (Alfredo E. Rodriguez, MD, PhD); Instituto Medico Adrogue (IMA), Adrogue, Buenos Aires (Juan Mieres, MD); Azienda Ospedaliero-Universitaria, Ospedali Riuniti Umberto I, GM Lancisi, Ancona, Italy (Tommaso Piva, MD); Cardiovascular Department of San Donato Hospital, Arezzo, Italy (Leonardo Bolognese, MD); Delta Hospital, Lagosanto, Italy (Gianfranco Percoco, MD); Azienda Ospedaliero-Universitaria, S. Anna Hospital, Ferrara, Italy (Gianluca Campo, MD); Department of Cardiology, Civic Hospital, Mirano, Italy (Giampaolo Pasquetto, MD); Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico S. Matteo, Pavia, Italy (Maurizio Ferrario, MD; Umberto Canosi, BSc; Ezio Bramucci, MD); Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy (Francesco Prati, MD, PhD; Fabrizio Imola, MD); San Camillo Hospital, Rome (Marco S. Nazzaro, MD, PhD; Roberto Violini, MD); San Giovanni Bosco Hospital, Turin, Italy (Salvatore Colangelo, MD, Giacomo Boccuzzi, MD); San Giovanni Battista Hospital, Turin (Guiseppe Biondi-Zoccai, MD; Imad Sheiban, MD); Department of Biomedical and Surgical Sciences, Section of Cardiology, University of Verona, Italy (Maurizio Anselmi, MD; Corrado Vassanelli, MD); Policlinico S. Marco, Zingonia, Italy (Nicoletta de Cesare, MD); La Paz University Hospital, Madrid, Spain (Raul Moreno, MD); Hospital Juan Ramón Jimenez, Huelva, Spain (J. F. Díaz Fernández, MD).