This new edition of a leading reference text covers all aspects of osteoporosis, from the basic science of bone biology to the latest clinical trials. Given the prevalence of osteoporotic fractures in the aging population and the rapid advances in clinical science, this edition is both comprehensive and timely. The 2 volumes include major sections on bone cell function and signaling mechanisms, structure and biomechanics, epidemiology and risk factors, pathophysiology, clinical evaluation and management, and the clinical pharmacology of therapeutic agents. More than 160 leading scholars and investigators in the field have authored 80 chapters. Extensive references cover the world literature through 2006. The overall organization of the volumes is clear and rational. Within the major sections, each chapter focuses on a particular topic, such as osteoblast biology, bone matrix proteins, cytokines and bone remodeling, or development of the skeleton. As one would expect, there is considerable overlap among the chapters, but this is mitigated by frequent cross-referencing in the text and an extensive index. Accordingly, the volumes are user-friendly for the reader seeking information on a particular issue.