Author Contributions: Dr Eng had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Assié,
Analysis and interpretation of data: Assié, LaFramboise, Platzer, Eng.
Drafting of the manuscript: Assié,
LaFramboise, Platzer, Eng.
Critical revision of the manuscript for important intellectual content: Platzer, Eng.
Statistical analysis: Assié,
Obtained funding: Eng.
Administrative, technical, or material support: Platzer, Eng.
Study supervision: Eng.
Financial Disclosures: None reported.
Funding/Support: This work was partially funded by grants 1P01CA97189-01A2 and 1P50/U54CA113001-01 from the National Cancer Institute and grant DAMD-02-1-0118 from the Department of Defense Prostate Cancer Research Program (Dr Eng). Dr Assié
was supported by clinical research fellowships from the Fondation de France and the Fédération Nationale des Centres de Lutte contre le Cancer. Dr Eng is a recipient of the Doris Duke Distinguished Clinical Scientist Award and is the Sondra J. and Stephen R. Hardis Chair of Cancer Genomic Medicine at the Cleveland Clinic.
Role of the Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management,
analysis, and interpretation of the data; and preparation or approval of the manuscript.
Additional Contributions: We thank Kevin Zbuk, MD, and Mohammed Orloff, PhD, Genomic Medicine Institute,
Cleveland Clinic, for critically reviewing drafts of this article on a voluntary basis.