Author Contributions: Dr Ressler had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. Drs Binder and Bradley contributed equally to this article.
Study concept and design: Binder, Bradley, Epstein, Heim, Schwartz, Cubells, Ressler.
Acquisition of data: Binder, Bradley, Deveau, Mercer, Tang, Gillespie, Heim, Cubells, Ressler.
Analysis and interpretation of data: Binder, Bradley, Liu, Epstein, Mercer, Heim, Nemeroff, Cubells, Ressler.
Drafting of the manuscript: Binder, Bradley, Epstein, Tang, Gillespie, Cubells, Ressler.
Critical revision of the manuscript for important intellectual content: Liu, Epstein, Deveau, Mercer, Heim, Nemeroff, Schwartz, Cubells, Ressler.
Statistical analysis: Binder, Bradley, Liu, Epstein, Tang, Gillespie, Ressler.
Obtained funding: Bradley, Heim, Nemeroff, Cubells, Ressler.
Administrative, technical, or material support: Bradley, Deveau, Mercer, Tang, Gillespie, Heim, Nemeroff, Schwartz, Cubells, Ressler.
Study supervision: Mercer, Nemeroff, Schwartz, Cubells, Ressler.
Financial Disclosures: Dr Binder reported receiving grant support or awards from Pfizer, GlaxoSmithKline, National Alliance in Research in Schizophrenia and Depression (NARSAD), the Doris Duke foundation, and the National Institute of Mental Health (NIMH), and has received speaker's honoraria from AstraZeneca. Dr Tang reports receiving grant support from NARSAD and speaker's honoraria from AstraZeneca, Eli Lilly, GlaxoSmithKline, Organon, Pfizer, and Xian-Janssen. Dr Gillespie reports receiving funding from APIRE/Wyeth, NARSAD, and National Institute on Drug Abuse (NIDA). Dr Heim reports receiving financial or grant support from NIMH, Centers for Disease Control and Prevention, NARSAD, the Anxiety Disorders Association of America, Eli Lilly, and Novartis. Dr Nemeroff reports serving on the Scientific Advisory Board for Quintiles, AstraZeneca, Forest Laboratories, Janssen/Ortho-McNeil, American Foundation for Suicide Prevention (AFSP), NARSAD, and PharmaNeuroboost. He holds equity, stock options, or stock in Novadel Pharma, Corcept, CeNeRx, PharmaNeuroboot, and Reevax; is on the board of directors of Novadel Pharma, Mt Cook Pharma, the AFSP, and the George West Mental Health Foundation; and is a grant recipient from the National Institutes of Health. Dr Ressler reports receiving awards, funding support, or both related to other studies from Howard Hughes Medical Institute, Lundbeck, Burroughs Wellcome Foundation, Pfizer, NARSAD, NIMH, and NIDA, and has a consulting agreement with Tikvah Therapeutics for N-methyl-D-aspartate–based therapeutics. No other authors reported any financial disclosures.
Funding/Support: This work was primarily supported by grant MH071537 from the National Institute of Mental Health. Support was also received by grants MH069884 (Dr Ressler), MH-42088, and MH-58922 (Dr Nemeroff) from the National Institute of Mental Health, DA015766 from the National Institute on Drug Abuse (Dr Cubells), Emory and Grady Memorial Hospital General Clinical Research Center, grant M01 RR00039 from the National Institutes of Health National Centers for Research Resources, and the Burroughs Wellcome Fund (Dr Ressler).
Role of the Sponsors: None of the above funding agencies had any role in the design and conduct of the study, in the collection, management, analysis, and interpretation of the data, or in the preparation, review, or approval of the manuscript.
Additional Contributions: Allen Graham, BS, Eboni Johnson, BS, Josh Castleberry, BS, Daniel Crain, BS, Abby Powers, BS, Nineequa Blanding, BS, Daphne Pierre, BS, Rachel Hershenberg, BS (all paid staff from the Grady Trauma Project, Grady Memorial Hospital, Atlanta, Georgia), and Tiina Berg, PhD (Department of Psychiatry, Emory University), provided excellent technical support.