In 2008, approximately 37 000 patients will be diagnosed with pancreatic adenocarcinoma in the United States, and most of these patients will succumb to this disease within the first year following diagnosis.1 Only approximately 7400
patients will have localized cancer, usually involving the head of the pancreas, and are candidates for surgery if the tumor is resectable,
as defined by the absence of vascular involvement.2 Such patients are candidates for complete resection of the primary cancer. The prognostic significance of an incomplete resection is well-defined (ie, the survival duration of those who undergo an incomplete [R1] resection is on average shorter than that of patients achieving a complete [R0] resection and in some series is no different than the survival of patients with locally advanced stage III disease who receive chemoradiation without surgery,
chemotherapy, or both).3,4 With optimal patient selection, improved surgical techniques, and modern perioperative care, many patients who undergo pancreatic resection will recover adequately to become candidates for postoperative adjuvant therapy and this, coupled with the high frequency of cancer recurrence following surgery, provides a strong impetus to offer such therapy to patients.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 10
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.