The history of modern medicine is riddled with stories of discovery,
skepticism, rejection, and, sometimes, redemption and acceptance.
For instance, the discovery of Helicobacter pylori by Marshall1 is a fairly recent example of initial rejection by the mainstream scientific community and ultimate redemption (as recognized by the Nobel Prize).
Similarly, reports from Japan in the 1980s and 1990s suggested that nonpolypoid (ie, flat or depressed) colorectal neoplasms (NP-CRNs)
were common and ominous.2,3 Depressed lesions commonly harbored in situ or submucosal carcinoma.
However, some western investigators were skeptical because such lesions were not commonly found in North American patient populations, and the rates of high-grade dysplasia in small flat polyps were low.4,5 In 1992, a prospective study from Nebraska found that although flat adenomas could be found with careful examination, none contained high-grade dysplasia.6 Subsequent studies from Sweden,7 Canada,8 the United States,9 and the United Kingdom10 reported that with careful examination technique,
flat and depressed lesions were indeed found in the West. Even though there was agreement that flat lesions are difficult to detect and might easily be missed with routine colonoscopy, the importance of such findings in the West remained uncertain but of concern.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Country-Specific Mortality and Growth Failure in Infancy and Yound Children and Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early dhildhood mortality and growth failure data and their association with maternal
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 7
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.