This Commentary on the psychopharmacological revolution focuses on 2 mysteries: fostering medication discovery and finding out how they work. When I entered psychiatric training in 1953 at Creedmoor State Hospital, a 6000-bed institution with few therapeutic aspirations,
psychotropic drugs were an impossible dream. For those individuals who have not had such an experience, an extremely morbid imagination is needed to conjure up that bedlam. It was rendered just tolerable by knowing that this training made one fit to be a candidate psychoanalyst.
The next 2 years were spent at the US Public Health Service Hospital in Lexington, Kentucky, a 1000-bed federal therapeutic prison for opioid addicts, which amazingly included the most advanced center for human psychopharmacological experimentation in the world. The Addiction Research Center, led by the rigorous scientists Wikler and Isbell,1 incisively demanded objective,
unbiased work and conducted pioneering studies of chlorpromazine,
reserpine, and lysergic acid diethylamide.
Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more
Subscribe for full-text access to content from 1998 forward and a host of useful features
Activate your current subscription (AMA members and current subscribers)
Purchase Online Access to this article for 24 hours
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 27
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
and access these and other features:
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.