Osteomyelitis is an inflammation of bone caused by an infecting organism. The infection may be limited to a single portion of the bone or may involve multiple areas. The infection is generally due to a single organism, but polymicrobial infections (caused by different and multiple bacteria or fungi) can occur,
especially in patients with diabetes. Persons of any age can develop a bone infection, although it is more common in children and persons older than 50 years. The February 20, 2008, issue of JAMA includes an article about the difficulties of identifying and diagnosing osteomyelitis in patients with diabetes.