Author Contributions: Dr Meade had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Meade, Cook,
Guyatt, Slutsky, Lapinsky, Stewart.
Acquisition of data: Meade, Arabi,
Cooper, Davies, Hand, Austin, Lapinsky, Baxter, Skrobik, Ronco, Stewart.
Analysis and interpretation of data: Meade, Cook, Guyatt, Slutsky, Davies, Zhou, Thabane, Austin, Russell,
Skrobik, Ronco, Stewart.
Drafting of the manuscript: Meade,
Cook, Guyatt, Stewart.
Critical revision of the manuscript for important intellectual content: Meade, Slutsky, Arabi, Cooper, Davies,
Hand, Zhou, Thabane, Austin, Lapinsky, Baxter, Russell, Skrobik, Ronco,
Statistical analysis: Zhou, Thabane.
Obtained funding: Meade, Stewart.
Administrative, technical, or material support: Meade, Cook, Guyatt, Slutsky, Arabi, Hand, Austin, Lapinsky, Skrobik,
Study supervision: Meade, Arabi, Cooper,
Austin, Baxter, Russell, Ronco, Stewart.
Financial Disclosures: None reported.
Lung Open Ventilation Study Investigators:principal investigators: M. O. Meade, T.
E. Stewart; steering committee: D. J. Cook,
G. H. Guyatt, M. O. Meade, T. E. Stewart, A. S. Slutsky; site investigators: Canada: Centre Hospitalier Universitaire de Sherbrooke—O. Lesur; Charles LeMoyne Hospital,
Montreal—C. Corbeil, G. Poirier; Hamilton Health Science, General Hospital—C. Bradley, M. O. Meade; Hamilton Health Sciences,
Henderson Hospital—G. Jones; Hamilton Health Sciences, McMaster—A.
Freitag; Hopital de l’Enfant Jesus, Quebec City—M. Lessard,
S. Langevin; Hopital Maisonneuve Rosemont, Montreal—B. Laufer,
Y. Skrobik; Hotel Dieu Grace, Windsor—J. Muscedere; Jewish General Hospital, Montreal—D. Laporta; London Health Sciences Centre,
University Hospital—D. Leasa; London Health Sciences Centre,
Victoria Hospital—C. Martin; Montreal General Hospital—D.
Evans; Mount Sinai Hospital, Toronto—S. Lapinsky, T. E. Stewart;
Ottawa Hospital, Civic Campus—R. Hodder; Ottawa Hospital, General Campus—A. Baxter; Royal Columbian Hospital, New Westminster—S.
Keenan; Royal Victoria Hospital, Montreal—S. Magder; St Joseph’s Healthcare, Hamilton—D. J. Cook; St. Michael's Hospital—C.
D. Mazer, M. Ward; St Paul's Hospital, Vancouver—J. A. Russell;
Sunnybrook Hospital—A. B. Cooper; Toronto General Hospital—J.
T. Granton; Toronto Western Hospital—N. D. Ferguson; University of Alberta Hospital, Edmonton—M. Jacka; Vancouver General Hospital—J.
J. Ronco; Vancouver Island Health Research Centre, Victoria—G.
Wood; Australia: Alfred Hospital, Melbourne—A. Davies, D. J.
Cooper; Royal Prince Alfred Hospital, Camperdown—C. Woolfe;
Western Hospital, Victoria—C. French; Saudi Arabia: Medical City King Fahad National Guard Hospital, Riyadh—A. A. Al-Shimemeri,
Y. M. Arabi, O. Dabbagh; methods center:
CLARITY Research, McMaster University, Hamilton—P. Austin, D.
J. Cook, G. H. Guyatt, L. E. Hand, M. O. Meade, L. Thabane, N. Zytaruk,
Q. Zhou; protocol review: R. Kaczmarek, R.
McDonald; data monitoring committee: R. Roberts (chair), R. Jaeschke, H. Kirpilani, N. MacIntyre; writing committee: D. J. Cook, G. H. Guyatt, L. E. Hand, M.
O. Meade, T. E. Stewart, L. Thabane, A. S. Slutsky.
Funding/Support: This study was supported by grants from the Canadian Institutes for Health Research and Hamilton Health Sciences Foundation. Dr Meade was a Peter Lougheed Scholar of the Medical Research Council of Canada during the period of this study. Drs Cook and Thabane are clinical trials mentors for the Canadian Institutes of Health Research.
Role of the Sponsors: The funding agencies had no role in the design and conduct of the study, in the collection,
analysis, or interpretation of data, or in the preparation, review,
or approval of the manuscript.