Study concept and design: Primrose, Gray, Rose, Corkhill, George, Mant.
Acquisition of data: Primrose, Fuller, Mant.
Analysis and interpretation of data: Primrose, Perera, Gray, Rose, Fuller, George, Mant.
Drafting of the manuscript: Primrose, Gray, George, Mant.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Primrose, Perera, Fuller, Mant.
Obtained funding: Primrose, Gray, Rose, George, Mant.
Administrative, technical, and material support: Fuller, Corkhill.
Study supervision: Primrose, George, Mant.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Rose reports board membership with GP Update Ltd. No other disclosures were reported.
FACS Trial Investigators: University of Southampton: Siân Pugh (surgical registrar), Louisa Little, Andrea Corkhill (clinical trial managers), Scott Regan, Jane Mellor (clinical trial coordinators); University of Oxford: Indika Pathiraja (clinical research fellow), Helen Campbell (research fellow in health economics); Oxford University Hospitals Trust: Tim James (head biomedical scientist), Helen Bungay (clinical radiologist). Participating NHS hospitals: Birmingham Heartlands Hospital (Gamal Barsoum); Castle Hill Hospital, Hull (John Hartley); Charing Cross Hospital (Peter Dawson); Cumberland Infirmary (Jonathan Nicoll); Darent Valley Hospital (Mike Parker); Derriford Hospital, Plymouth (Mark Coleman); Grantham and District Hospital (Dilip Mathur); Harrogate District Hospital (Jon Harrison); Hillingdon Hospital (Yasser Mohsen); Hinchingbrooke Hospital (Litee Tan); King’s Mill Hospital (Mukul Dube); Leeds St James (Simon Ambrose); Leeds General Infirmary (Paul Finan); Leighton General Hospital (Arif Khan); Maidstone Hospital (Mark Hill); Croydon University Hospital (formerly Mayday Hospital) (Muti Abulafi); Newham University Hospital (Roger Le Fur); Oxford Radcliffe Hospitals (Neil Mortensen); Queen Alexandra/Portsmouth (Daniel O’Leary); Queen Elizabeth Hospital, Birmingham (Neil Steven); Queens Hospital Burton-on-Trent (Stelios Vakis); Queens Medical Centre, Nottingham (John Scholefield); Royal Cornwall Hospital (Ponnandai Arumugam); Royal Derby Hospital (Jonathan Lund); Royal Shrewsbury (Trevor Hunt); Russels Hall Hospital (David Ferry); Scarborough Hospital (Ian Renwick); Southampton General Hospital (Paul Nichols); St Mark’s Hospital, Harrow (John Northover, Arun Gupta); St Peter’s Hospital, Chertsey (Philip Bearn); St Richard’s Hospital, Chichester (Neil Cripps); Taunton and Somerset (Mary Tighe); Torbay Hospital (Rupert Pullan); Manor Hospital, Walsall (Jonathan Stewart); Warrington Hospital (Barry Taylor); West Middlesex Hospital (Subramanian Ramesh); Wexham Park Hospital (Harpreet Wasan); Worcester Royal Hospital (Stephen Lake); Wycombe General Hospital (Andrew Weaver). Data Monitoring and Ethics Committee: Jack Hardcastle, Nottingham University; Michael Campbell, Sheffield University; David Whynes, Nottingham University.
Funding/Support: The project was funded by the UK National Institute for Health Research Health Technology Assessment (NIHR HTA) program (project No. 99/10/99).
Role of the Sponsors: The NIHR HTA had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.
Disclaimer: The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the HTA program, the NIHR, the NHS, or the Department of Health.
Additional Contributions: We acknowledge the invaluable contributions of the local NIHR cancer research networks, NHS trusts, and patients who agreed to participate in this trial.