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Comment & Response |

Formulation of Treatment Recommendations for Statins

Mark D. Huffman, MD, MPH1; Shah Ebrahim, BM, BS, MSc, DM2; Kay Dickersin, PhD3
[+] Author Affiliations
1Northwestern University Feinberg School of Medicine, Chicago, Illinois
2London School of Hygiene and Tropical Medicine, London, England
3Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
JAMA. 2014;311(3):305-306. doi:10.1001/jama.2013.284443.
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To the Editor The Viewpoint on formulation of statin guidelines by Drs Ridker and Wilson1 may have unintentionally implied to the clinical community that it is acceptable to focus on selected evidence over the totality of the evidence. Ridker and Wilson’s example of trial-based recommendations for primary cardiovascular disease prevention includes subgroups identified through only 6 trials; however, a recent Cochrane Collaboration systematic review2 on the effect of statins for primary cardiovascular disease prevention identified 18 trials.


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January 15, 2014
Paul M Ridker, MD, MPH; Peter W. F. Wilson, MD
1Center for Cardiovascular Disease Prevention, Brigham and Women’s Hospital, Boston, Massachusetts
2Emory Clinical Cardiovascular Research Institute, Atlanta, Georgia
JAMA. 2014;311(3):306. doi:10.1001/jama.2013.284481.
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