Among the 3 first-line smoking cessation treatments (nicotine replacement therapy [NRT], bupropion, and varenicline), which is most effective in helping people who smoke achieve and maintain abstinence from smoking for at least 6 months, and what serious adverse events are associated with each?
Higher rates of smoking cessation were associated with NRT (17.6%) and bupropion (19.1%) compared with placebo (10.6%). Varenicline (27.6%) and combination NRT (31.5%) (eg, patch plus inhaler) were most effective for achieving smoking cessation. None of the therapies was associated with an increased rate of serious adverse events.
Source: Data have been adapted with permission from the Cochrane Collaboration and Wiley.1 NA indicates not available; NRT, nicotine replacement therapy (any type, single or combination). Credible interval is the Bayesian equivalent of confidence interval and is interpreted the same way as confidence interval. For varenicline vs NRT, indirect comparison was generated by the network analysis.
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