Study concept and design: Dysken, Sano, Asthana, Vertrees, Schellenberg, Peduzzi, Guarino.
Acquisition of data: Asthana, Pallaki, Llorente, Love, Schellenberg, McCarten, Malphurs, Prieto, Chen, Loreck, Trapp, Bakshi, Mintzer, Heidebrink, Vidal-Cardona, Arroyo, Cruz, Zachariah, Kowall, Chopra, Craft, Thielke, Turvey, Woodman, Monnell, Gordon, Segal.
Analysis and interpretation of data: Dysken, Asthana, Sano, Vertrees, Pallaki, Llorente, Love, Schellenberg, McCarten, Malphurs, Chen, Loreck, Trapp, Bakshi, Mintzer, Heidebrink, Arroyo, Cruz, Kowall, Chopra, Craft, Turvey, Woodman, Monnell, Gordon, Tomaska, Segal, Peduzzi, Guarino.
Drafting of the manuscript: Dysken, Guarino.
Critical revision of the manuscript for important intellectual content: Dysken, Sano, Asthana, Vertrees, Pallaki, Llorente, Love, Schellenberg, McCarten, Malphurs, Prieto, Chen, Loreck, Trapp, Bakshi, Mintzer, Heidebrink, Vidal-Cardona, Arroyo, Cruz, Zachariah, Kowall, Chopra, Craft, Thielke, Turvey, Woodman, Monnell, Gordon, Segal, Peduzzi, Guarino.
Statistical analysis: Peduzzi, Guarino.
Obtained funding: Dysken, Vertrees, Peduzzi, Guarino.
Administrative, technical, or material support: Dysken, Sano, Asthana, Vertrees, Pallaki, Llorente, Love, Schellenberg, McCarten, Malphurs, Prieto, Chen, Loreck, Trapp, Bakshi, Mintzer, Vidal-Cardona, Arroyo, Cruz, Zachariah, Kowall, Chopra, Thielke, Woodman, Gordon, Tomaska, Segal, Guarino.
Study supervision: Dysken, Sano, Asthana, Vertrees, Pallaki, Llorente, Love, Schellenberg, McCarten, Malphurs, Chen, Loreck, Trapp, Bakshi, Mintzer, Heidebrink, Vidal-Cardona, Arroyo, Cruz, Kowall, Chopra, Craft, Turvey, Monnell, Gordon, Guarino.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Sano reported having been a board member for Medication and a data and safety monitoring board member for the ASPREE study; having received consulting fees from Takeda, Medpace, sanofi-aventis, Trans-tech Pharma, Elsai Pharmaceutical, Eli Lilly, Neurocog, Targacept, and Vital Images; having provided expert testimony for McDermott Will & Emory; having received grants from the Alzheimer’s Association; and having received speakers’ fees or travel expenses from the University of New England, Medical College of South Carolina, International Psychogeriatric Association, and Alzheimer’s Association. Dr Asthana reported having received grant support from Pfizer, Elan, Merck, Eli Lilly, Eisai, and Wyeth and having served as associate editor for a textbook from McGraw Hill Publishers. Dr Mintzer reported having been vice president of clinical affairs for NeuroQuest; being majority owner of BioPharma Connex; and having received grants from the National Institute on Aging, Takeda Global Research and Development Center, Pfizer, Genentech, Merck, Accera, Elan Pharma International, Avanir Pharmaceuticals, Hoffmann-LaRoche, Eli Lilly, Novartis, Baxter Healthcare, Wyeth, and Janssen AI Research and Development. Dr Chopra reported having received a Boston University Alzheimer's Disease Core Center Pilot Grant. No other disclosures were reported.
Funding/Support: VA TEAM-AD was funded by the Veterans Affairs Cooperative Studies Program, Office of Research and Development, Clinical Science R&D. Forest Research Institute, a Division of Forest Laboratories, donated the memantine and matching placebo tablets. DSM Nutritional Products donated the DL-alpha-tocopheryl acetate oil and funding for the purchase of the soybean oil from Arista Industries.
Role of the Sponsors: The US Department of Veterans Affairs Cooperative Studies Program participated in the design and oversaw the conduct of the study. The Veterans Affairs Cooperative Studies Program, Forest Research Institute, and DSM Nutritional Products had no input into data collection, management, analysis, and interpretation of the data or preparation, review, or approval of the manuscript.
VA TEAM-AD Study:Planning Committee: M. Dysken (Study Chair), S. Asthana, P. Guarino, J. Hanlon, M. Kunik, P. Lavori, P. Peduzzi, E. Perry, M. Sano, G. Schellenberg, T. Sunderland, G. Vatassery (deceased), J. Vertrees, L. Volicer. Executive Committee: M. Dysken (Chair), S. Asthana, P. Guarino, M. Llorente, S. Love, M. Pallaki, M. Sano, G. Schellenberg, G. Vatassery (deceased), J. Vertrees. Data Monitoring Committee: K. Kieburtz (Chair), C. Kawas, E. Lonn (resigned), P. Rabins, J. Rochon, D. Sultzer, R. Thomas. VA Cooperative Studies Program Human Rights Committee, West Haven, Connecticut: R. Marottoli (Chair), H. Allore, D. Beckwith, W. Farrell, R. Feldman, R. Mehta, J. Neiderman, E. Perry, S. Kasl, M. Zeman. VA Site Investigators and Coordinators: Ann Arbor, Michigan: J. Heidebrink, R. S. Turner, N. Barbas, C. Bloehm, J. Lord, K. Belanger, N. Ricci, C. Nwankwo, C. Fletcher; Baltimore, Maryland: D. Loreck, L. Katzel, K. Anderson, G. Kavanagh, S. Carney, A. Loreck. (Bay Pines, Florida) A. Cruz, S. Reddy, N. Purohit, R. Tamayo, K. Monnell, S. Huda, S. Zachariah, W.C. McCarthy; Boston, Massachusetts: N. Kowall, M. Chopra, B. Seltzer (deceased), K. Kolbe; Charleston, South Carolina: J. Mintzer, O. Brawman-Mintzer, A. Senseney, D. Courtney, M. Stuckey, S. Russell, J. A. Sweeney;. Cleveland, Ohio: M. Pallaki, P. Chen, T. Hornick, T. Dolinar, L. Abood, A. Coulter, S. Truax, D. Davis; Dallas, Texas; G. Trapp, R. Bakshi, L. Moody, N. Flye, D. Turner-Knight; Iowa City, Iowa: C. Turvey, C. Woodman, A. Ray, K. Ekstam Smith, N. Suiter; Madison, Wisconsin: S. Asthana, C. Gleason, S. Barczi, C. Carlsson, N. Lane, M. Wroblewski, Z. Zugin, J. J. Fruehling; Miami, Florida: J. Malphurs, M. Llorente, F. Adan, S. Prieto, M. Horvath, D. Santiago, G. Athappilly, A. Cortes, A. Vazquez, R. Dreize, F. Ostovary, E. Palaois, M. Oliveira, J. Pino, L. Claude; Minneapolis, Minnesota: J. McCarten, H. Fink, C. Erickson, L. Becker-Grandle; Salisbury, North Carolina: K. Monnell, K. Gordon, K. Phillips, D. Eknoyan; San Juan, Puerto Rico: A. Vidal-Cardona, L. Arroyo, A. Melendez, L. Santiago, B. Padilla; Seattle, Washington: S. Craft, J. Breitner, S. Thielke, K. Enstrom, J. Tidwell, R. Bridgan, K. Bowton, D. Dahl. Study Chair’s Office, VA Health Care System, Minneapolis: M. Dysken (Study Chair), S. Love, J. Tomaska. Central Laboratory, VA Health Care System, Minneapolis: G. Vatassery (deceased), Y. Segal, E. Smith, H. Quach. VA Cooperative Studies Program Coordinating Center, VA Connecticut Healthcare System, West Haven: P. Guarino (Director, Study Biostatistician), M. Antonelli, E. Jobes, C. Joncas, S. Joyner, K. Kirkwood, P. Peduzzi, M. Perry, E. Petrokaitis, J. Russo, J. Scholl, S. Yang, S. Zellner. VA Cooperative Studies Program Clinical Research Pharmacy Coordinating Center, Albuquerque, New Mexico: M. Sather (Director), J. Vertrees (Study Clinical Research Pharmacist), S. Campbell, D. Conner, E. Copeland, A. Davis S. Jenkins, B. Matura. VA Cooperative Studies Program Site Monitoring, Auditing and Review Team, Albuquerque: C. Haakenson, D. Krueger. VA Cooperative Studies Program Central Biorepository (MAVERIC), VA Healthcare System, Boston: M. Brophy (Director), D. Humphries, D. Govan. VA Cooperative Studies Program DNA Bank Coordinating Center, VAMC Palo Alto, CA: J. Cockroft, S. Bobra, A. Baylosis, R. Dodson, I. Belitskaya-Levy. VA Office of Research and Development, Clinical Science Research and Development, Washington, DC: T. O’Leary (Director, Deputy Chief Research and Development Officer), G. Huang (Deputy Director, Cooperative Studies Program).
Correction: This article was corrected online February 5, 2014.