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Comment & Response |

Combination Pill for Cardiovascular Disease—Reply

Simon Thom, MB,BS, MD1; Anthony Rodgers, MD, PhD2
[+] Author Affiliations
1International Centre for Circulatory Health, Imperial College London, London, England
2George Institute for Global Health, Sydney, Australia
JAMA. 2014;311(1):93-94. doi:10.1001/jama.2013.283146.
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In Reply Drs Tsujimoto and Yamamoto-Honda note that improvements in adherence are of benefit in terms of increasing uptake of proven antiplatelet therapy, but question the importance of the improvements in mean LDL-C level and SBP. In contrast to their suggestion, in high-risk cardiovascular patients there is clear evidence of benefits of blood pressure lowering in patients without hypertension and of more vs less blood pressure lowering13; similarly, there are benefits of LDL-C level lowering in patients without hyperlipidemia and of more vs less LDL-C level lowering.4,5


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January 1, 2014
Tetsuro Tsujimoto, MD; Ritsuko Yamamoto-Honda, MD, PhD
1Department of Diabetes and Metabolic Medicine, National Center for Global Health and Medicine, Tokyo, Japan
JAMA. 2014;311(1):92-93. doi:10.1001/jama.2013.283130.
January 1, 2014
Michelle Carey, PharmD
1Family Medicine Pharmacy Residency Program, ProMedica Toledo Hospital, Toledo, Ohio
JAMA. 2014;311(1):93. doi:10.1001/jama.2013.283133.
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