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Comment & Response |

Combination Pill for Cardiovascular Disease

Michelle Carey, PharmD1
[+] Author Affiliations
1Family Medicine Pharmacy Residency Program, ProMedica Toledo Hospital, Toledo, Ohio
JAMA. 2014;311(1):93. doi:10.1001/jama.2013.283133.
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To the Editor Dr Thom and colleagues1 addressed medication adherence by analyzing the effects of an FDC pill for patients with or at high risk of cardiovascular disease. Thom et al1 assessed participants at 6-month intervals for a minimum of 12 months up to a maximum of 24 months from the initial intervention.

Adherence was addressed by self-report in the week prior to each of these visits. Thus, for participants assessed at all end points, adherence was evaluated for a maximum of 5 weeks out of a total 104 weeks of enrollment. Although the authors stated that the modest improvement in SBP and LDL-C level justified this method, failure to include data on medication adherence throughout the entire study period may have biased the results toward a more favorable outcome.


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January 1, 2014
Simon Thom, MB,BS, MD; Anthony Rodgers, MD, PhD
1International Centre for Circulatory Health, Imperial College London, London, England
2George Institute for Global Health, Sydney, Australia
JAMA. 2014;311(1):93-94. doi:10.1001/jama.2013.283146.
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