As in previous years, in July 2014 JAMA will publish a theme issue dedicated to HIV/AIDS research, which will coincide with the 20th International AIDS Conference to be held in Melbourne, Australia.6 Authors are invited to submit evidence-based manuscripts on topics of HIV-related prevention and treatment for consideration for publication in this issue. Original research, especially randomized clinical trials of HIV treatment, will receive the highest priority for publication. Rigorous studies on the epidemiology and management of HIV/hepatitis C coinfection and HIV/tuberculosis coinfection also are of major interest. Reports of investigations on HIV basic science and its clinical application, behavioral and preventive intervention approaches, and issues related to HIV in international settings also are welcome. Systematic reviews and scholarly Viewpoints on these topics, as well as on topics relevant to clinical, educational, policy, and financial aspects of HIV/AIDS also would be of interest.