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Comment & Response |

Weight Loss Treatment in Obese Adults—Reply

Caroline M. Apovian, MD1; Louis J. Aronne, MD2
[+] Author Affiliations
1Section of Endocrinology, Diabetes, and Nutrition, Boston University School of Medicine, Boston, Massachusetts
2Department of Medicine, Weill Cornell Medical College, New York, New York
JAMA. 2013;310(23):2568. doi:10.1001/jama.2013.282261.
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In Reply As Dr Gadde correctly notes, we stated in our Commentary that 58 participants in the trial1 were nonadherent to the treatment protocol for various reasons. In the trial, 48 participants dropped out, of whom 41 returned for the final visit. Therefore, 7 were lost to follow-up.

The authors identified an additional 10 participants who discontinued use of the blinded study drug but remained in the study as “study completers.” They only counted the 48 patients as dropouts in calculating the study completion rate of 96.9%. The 96.9% therefore included the 10 participants who discontinued taking the study drug yet completed study visits to the end of the trial.


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December 18, 2013
Kishore M. Gadde, MD
1Duke University Medical Center, Durham, North Carolina
JAMA. 2013;310(23):2568. doi:10.1001/jama.2013.282258.
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