There remains a substantial and widening gap between the epidemiologic, clinical, and socioeconomic importance of heart failure hospitalizations and the lack of therapeutic progress made over the last few decades. Heart failure is the primary cause of more than one million US hospitalizations annually and is a contributory diagnosis in an additional 2 million to 3 million hospitalizations.1 These figures are projected to increase with the aging population. The cardiovascular mortality and readmission rate for patients recently discharged following an admission for heart failure is approximately 25% at 6 months, and all-cause mortality exceeds 30% at 1 year. These figures have remained largely unchanged over the last 2 decades.2,3
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