Cardiovascular medicine currently lacks high-quality evidence needed to inform many important decisions that patients, physicians, and other health care practitioners and health systems must make regarding the prevention and treatment of cardiovascular disease.1 At the same time, clinical research costs are escalating while government and industry funding is increasingly constrained. Bridging this gap between the need for evidence and the resources available to generate it will require harnessing creative solutions that leverage changes already under way in health care delivery.2 In this Viewpoint, we discuss key limitations of the current research system and describe an evolving national infrastructure with the potential to increase health research substantially.
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