0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Medical News & Perspectives |

2013 Nobel Prize Recognizes Work of Scientists Who Illuminated Molecular Transport System of Cells

M. J. Friedrich
JAMA. 2013;310(19):2027-2029. doi:10.1001/jama.2013.281691.
Text Size: A A A
Published online

Extract

Three scientists who worked independently to understand the basic mechanisms involved in the production and transport of proteins and other molecules within and beyond the cell have been awarded the Nobel Prize in Physiology or Medicine for 2013.

James E. Rothman, PhD, of Yale University, New Haven, Connecticut; Randy W. Schekman, PhD, of the University of California, Berkeley; and Thomas C. Südhof, MD, PhD, of Stanford University, Palo Alto, California, each puzzled out a slightly different aspect of the vesicle transport system that lies at the heart of how cells function and communicate. Schekman discovered a set of genes needed for vesicle transport, Rothman discovered the protein machinery that vesicles rely on to fuse with their targets and deliver their cargo, and Südhof discovered the signals that direct vesicles to release their cargo with precision.

Figures in this Article

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
/>
First page PDF preview

Figures

Place holder to copy figure label and caption

Graphic Jump LocationImage not available.

When moving molecules within the cell, a vesicle buds from one membrane (such as from an organelle like the endoplasmic reticulum), docks and fuses with a target membrane of another organelle, and releases its contents. A vesicle exporting molecular cargo from the cell docks and fuses with the cell’s outer membrane and releases the molecules outside the cell, where they can bind to receptors on a target cell.

Tables

References

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
Jobs
brightcove.createExperiences();