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Research Letter |

Subgroup Analyses in Trial Reports Comparing Percutaneous Coronary Intervention With Coronary Artery Bypass Surgery

Stuart J. Head, PhD1; Sanjay Kaul, MD2; Jan G. P. Tijssen, PhD3; Patrick W. Serruys, MD, PhD4; A. Pieter Kappetein, MD, PhD1
[+] Author Affiliations
1Department of Cardio-Thoracic Surgery, Erasmus University Medical Center, Rotterdam, the Netherlands
2Division of Cardiology, Cedars-Sinai Medical Center, Los Angeles, California
3Department of Cardiology, Academic Medical Center of the University of Amsterdam, Amsterdam, the Netherlands
4Department of Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands
JAMA. 2013;310(19):2097-2098. doi:10.1001/jama.2013.281630.
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Subgroup analyses within randomized clinical trials (RCTs) may not be valid,1,2 although they may identify important treatment heterogeneity. Reviews of subgroup analyses in primary reports of RCTs have found low credibility due to methodological or reporting issues.2 Subgroup analyses may also be presented in separate reports of extended follow-up beyond the primary end point or specific subgroups of patients.

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