Exactly 100 years ago, one of the most important lines of research in cardiology began—the story of cholesterol. This complicated saga has many twists and turns and much controversy, even continuing to today. It is the tale of a simple compound that has been the subject of thousands of papers and several Nobel prizes. Every type of researcher from chemists to basic scientists to epidemiologists to trialists to health services researchers and health economists has played an important role in the progression of this drama. Billions of dollars have been invested in developing and made in commercializing technologies to measure and modify the level of this molecule that has become part of the common vernacular.
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