Published Online: November 9, 2013. doi:10.1001/jama.2013.282426.
Study concept and design: Gandhi, Fleet, Bailey, Rehman, Garg.
Acquisition of data: Gandhi, McArthur, Garg.
Analysis and interpretation of data: Gandhi, Fleet, Bailey, McArthur, Wald, Garg.
Drafting of the manuscript: Gandhi, Bailey, Garg.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: McArthur, Garg.
Obtained funding: Garg.
Administrative, technical, or material support: Fleet, Wald, Rehman, Garg.
Study supervision: Garg.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Wald reported receiving unrestricted research funding and speaking fees from Alere, and honoraria from Thrasos for serving on a scientific advisory board. Dr Garg reported receiving an investigator-initiated grant from Astellas and Roche to support a Canadian Institutes of Health Research study in living kidney donors, and his institution received unrestricted research funding from Pfizer. No other disclosures were reported.
Funding/Support: This project was conducted at the Institute for Clinical Evaluative Sciences (ICES) Western Site. The ICES is funded by an annual grant from the Ontario Ministry of Health and Long-term Care. ICES Western is funded by an operating grant from the Academic Medical Organization of Southwestern Ontario. This project was conducted with members of the provincial ICES Kidney, Dialysis, and Transplantation Research Program, which receives programmatic grant funding from the Canadian Institutes of Health Research.
Role of the Sponsor: The sponsors had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Disclaimer: The opinions, results, and conclusions are those of the authors, and no endorsement by the Institute for Clinical Evaluative Sciences, Ontario Ministry of Health and Long-Term Care, or Academic Medical Organization of Southwestern Ontario is intended or should be inferred.
Additional Contributions: We thank Brogan Inc, Ottawa, for use of its drug product and therapeutic class database. We thank Gamma Dynacare for their use of the outpatient laboratory database and the team at London Health Sciences Centre, St Joseph’s Health Care, and the Thames Valley Hospitals for providing access to the Cerner laboratory database. We thank Stephanie Dixon, PhD, Lihua Li, MSc, and Salimah Shariff, PhD (all from ICES Western in London, Canada), for administrative support, analytic advice, and graphing contributions to this article. None received compensation for their role in the study.