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Comment & Response |

Acute Ischemic Stroke and Timing of Treatment—Reply

Jeffrey L. Saver, MD1; Gregg C. Fonarow, MD2; Lee H. Schwamm, MD3
[+] Author Affiliations
1Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California
2Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California
3Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts
JAMA. 2013;310(17):1856-1857. doi:10.1001/jama.2013.278898.
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In Reply Dr Radecki raises the interesting question of whether inclusion in the GWTG-Stroke registry cohort of a small proportion of patients who actually had stroke mimicking conditions or TIAs might have inflated the study’s estimates of the relationship of onset to lytic treatment time and clinical outcome. The available evidence indicates it did not.

First, patients whose final diagnosis was a stroke mimicking condition were not included in the GWTG-Stroke registry during the study period, even if they had received thrombolysis, so their contribution to the data was negligible.


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November 6, 2013
Ryan P. Radecki, MD
1University of Texas Health Science Center, Houston
JAMA. 2013;310(17):1855-1856. doi:10.1001/jama.2013.278893.
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