Published Online: October 28, 2013. doi:10.1001/jama.2013.281422.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported.
Acknowledgement: We express gratitude to Gordon Guyatt, MD, MSc, McMaster University, Hamilton, Ontario, Canada, for his generous and elegant review and advice about the content of this editorial. Dr Guyatt was not compensated for his work in association with this article.
Disclosures: The authors participate in the international GRADE Working Group that develops methodological innovations and standards in guideline development. The KER UNIT, in which all 3 authors work, contracts with nonprofit professional organizations and federal entities to conduct systematic reviews and offer methodological advice in support of their guideline development efforts.