Study concept and design: Sprenger, Wiech, Bingel.
Acquisition of data: Kessner, Sprenger.
Analysis and interpretation of data: Kessner, Sprenger, Wrobel, Wiech, Bingel.
Drafting of the manuscript: Kessner, Wiech, Bingel.
Critical revision of the manuscript for important intellectual content: Sprenger, Wrobel, Wiech, Bingel.
Statistical analysis: Kessner, Wrobel.
Obtained funding: Bingel.
Administrative, technical, or material support: Kessner, Sprenger.
Study supervision: Wiech, Bingel.
Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Wiech reported having received payment from various congresses for reimbursement of travel expenses. Dr Bingel reported having received payments for lectures about pain and placebo responses from Grunenthal and Bayer and having had a consultant contract about placebo and pain with the company Bionorica. No other disclosures were reported.
Funding/Support: This work (NCT01886014) was supported by grants from the German Research Foundation (FO-1328, BI 789/2-1) and the Federal Ministry of Education and Research (01GQ0808). Dr Wiech is Senior Research Fellow at the University of Bath and is funded by a University of Bath Prize Fellowship to the Centre for Pain Research.
Trial Registration: clinicaltrials.gov Identifier: NCT01886014
Additional Contributions: We thank Matthias Gamer, PhD, at the Department for Systems Neuroscience, Hamburg, for advice with the oxytocin intervention. He was not compensated for his contribution.