Fetal growth restriction and inflammation may be more important contributors to the development of cerebral palsy than previously recognized, suggests a study funded by the National Institute of Neurological Disorders and Stroke.
Events that restrict or stop the supply of oxygen to a fetus or a newborn have been linked to the development of cerebral palsy. But recently investigators have probed other potential contributors.
The new study by a multinational group of researchers looked specifically at factors associated with cerebral palsy in singleton infants born at 35 weeks gestation or later (McIntyre S et al. Obstet Gynecol. 2013;122:869-877). To do this, the researchers identified 494 individuals born during this time window who had cerebral palsy, 508 matched controls, 100 individuals who died in the neonatal period, and 73 stillbirths, all from Western Australia.